PXE國際關(guān)于彈性假黃瘤(PXE)的研究團隊，對其的病因提出了現有的兩種假設：積極的循環(huán)代謝產(chǎn)物或者組織特異性功能障礙。任務(wù)要求提供數據來(lái)求證這兩種假設或其中之一。根據各地的發(fā)病機制進(jìn)行實(shí)驗，進(jìn)一步了解PXE的病因。
這項任務(wù)保證至少會(huì )獎勵一名挑戰者，并且，除了任務(wù)獎金之外，PXE國際還將對中標者給予PXE的研究經(jīng)費資助。
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PXE – Evaluating Hypotheses and Suggesting Experiments for a Rare Disease
TAGS: Computer Science/Information Technology, Chemistry, Global Health, Nature, Public Good, Life Sciences, Ideation
AWARD: $7,000 USD | DEADLINE: 11/30/12 | ACTIVE SOLVERS: 38 | POSTED: 10/31/12
The Seeker, PXE International, the primary group responsible for funding PXE research, presents two existing hypotheses (an active circulating metabolite(s) or a tissue-specific dysfunction) for the rare disease Pseudoxanthoma Elasticum (PXE). The Seeker requests that Solvers present evidence favoring one of the two hypotheses, then provide additional experiments to conduct to further knowledge around the disease mechanism.
This is an Ideation Challenge with a guaranteed award for at least one submitted solution. In addition to the Challenge award, PXE International will also assist finalists in efforts to obtain funding for PXE-related research.
Detailed Description & Requirements
INTRODUCTION TO PXE
Pseudoxanthoma Elasticum (PXE) is a recessive genetic disorder with signs and symptoms that mimic many aspects of the normal aging process, but at a much younger age (when people are roughly between 10 and 20 years old). Specifically, the disease is characterized by fragmentation and mineralization of elastic fibers in certain tissues. Some of the more common symptoms, in general order that they occur, are:
Wet-type macular degeneration
Skin wrinkling
Calcification of blood vessels
Cardiovascular disease
PXE is a rare disease with an estimated patient population of 12,000 people. Given the small number of people with the disease, it has not been the subject of research by for-profit pharmaceutical and biotech companies.
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